乳糜泻影响全球约1.4%的人口。它是唯一已知环境触发因素(麸质)的自身免疫性胃肠疾病。治疗完全依赖终身严格的无麸质饮食。尽管无麸质饮食管理的原则已明确,但严格依从率的报告差异较大,约为42%至91%,具体取决于所使用的定义和评估方法。若未得到妥善管理,乳糜泻与一系列全身并发症相关,包括营养缺乏、骨病、皮肤表现、内分泌疾病及恶性肿瘤。
参考文献:
- Singh P, Arora A, Strand TA, et al. Global prevalence of celiac disease: systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2018;16:823-836.
- Hall NJ, Rubin G, Charnock A. Systematic review: adherence to a gluten-free diet in adult patients with coeliac disease. Aliment Pharmacol Ther. 2009;30:315-330.
- Lebwohl B, Sanders DS, Green PHR. Coeliac disease. Lancet. 2018;391:70-81.
- National Institute for Health and Care Excellence. Type 1 diabetes in adults: diagnosis and management (NG17). NICE, London, 2022.
- National Institute for Health and Care Excellence. Irritable bowel syndrome in adults: diagnosis and management (CG61). NICE, London, 2017.
- Rose C, Law GU, Howard RA. The psychosocial experiences of adults diagnosed with coeliac disease: a qualitative evidence synthesis. Qual Life Res. 2024;33:1-16.
- Clappison E, Hadjivassiliou M, Zis P. Psychiatric manifestations of coeliac disease: a systematic review and meta-analysis. Nutrients. 2020;12:142.
- Addolorato G, Capristo E, Ghittoni G, et al. Anxiety but not depression decreases in coeliac patients after one-year gluten-free diet: a longitudinal study. Scand J Gastroenterol. 2001;36:502-506.
- Kerswell NL, Strodl E. Emotion and its regulation predicts gluten-free diet adherence in adults with coeliac disease. Health Psychol Behav Med. 2015;3:52-68.
- Sainsbury K, Mullan B. Measuring beliefs about gluten free diet adherence in adult coeliac disease using the theory of planned behaviour. Appetite. 2011;56:476-483.
- Sainsbury K, Mullan B, Sharpe L. A randomized controlled trial of a theory-based intervention to improve gluten-free diet adherence. Am J Gastroenterol. 2013;108:811-817.
- Chey WD, Kurlander J, Eswaran S. Integrated care for disorders of gut–brain interaction. Lancet Gastroenterol Hepatol. 2020;5:876-877.
- National Institute for Health and Care Research. Designing integrated dietetic and psychological NHS pathways for adults living with coeliac disease (NIHR205380). NIHR, London, 2025.
【全文结束】

