高血压相关的脑血管变化与认知障碍 - 心脑血管

高血压相关的脑血管变化与认知障碍Hypertension-Associated Cerebrovascular Changes and Cognitive Impairment | EUROPEAN JOURNAL OF MODERN MEDICINE AND PRACTICE

环球医讯 / 心脑血管来源：inovatus.es乌兹别克斯坦 - 英文2026-10-10 22:32:24 - 阅读时长7分钟 - 3457字

本研究评估了不同高血压分期患者中磁共振成像检测的白质高信号与认知障碍之间的关系，发现白质高信号严重程度与蒙特利尔认知评估评分降低呈显著负相关，证实长期高血压导致的结构性脑血管变化与执行功能障碍和加工速度减慢相关，提示对高血压患者早期进行神经影像学和认知筛查可能有助于改善血管性痴呆的预防策略。

动脉高血压是脑小血管病和血管性认知障碍的主要可改变危险因素。慢性血压升高会导致内皮功能障碍、血脑屏障破坏、白质损伤和进行性认知下降。本研究旨在评估不同高血压分期患者中磁共振成像检测的白质高信号与认知障碍之间的关系。共检查了120名年龄45-70岁的患者。认知功能采用蒙特利尔认知评估量表进行评估，MRI结果采用Fazekas量表分级进行分析。结果发现白质高信号严重程度与MoCA评分降低之间存在统计学显著相关性（r = -0.62, p < 0.01）。研究结果证实，长期高血压会导致与执行功能障碍和加工速度减慢相关的结构性脑血管变化。对高血压患者进行早期神经影像学和认知筛查可改善血管性痴呆的预防策略。

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