不同发育阶段干细胞的特征Features of stem cells at different stages of ontogenesis | The Journal of V.N.Karazin Kharkiv National University. Series «Biology»

不同发育阶段干细胞的特征

作者： N. V. Kolot

关键词： 干细胞；个体发育；衰老

摘要

在个体发育过程中，人类和哺乳动物的所有器官和组织均保留着作为干细胞"微小包含物"的胚胎组织"前体"。干细胞参与维持各个发育阶段的细胞稳态，这种稳态基于细胞的持续自我更新。生物体内存在干细胞并不能使其免受个体发育的不可逆阶段——衰老的影响。关键问题在于衰老过程中干细胞发生了哪些变化，以及这些与年龄相关的变化在多大程度上源于其体细胞微环境。本文讨论并分析了显示干细胞特性及其在个体发育过程中微环境变化的数据，同时系统评述了涉及干细胞的老年学研究成果。

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